Table 3 of Sagong, Mol Vis 2011; 17:2808-2817.

Table 3. Allele and genotype association analysis between controls versus XFS and controls versus XFG.

  Control (n=146) XFS (n=28) XFG (n=61)
SNP Count (proportion) Count (proportion) p value OR (95% CI) Count (proportion) p value OR (95% CI)
rs1048661
Allele
T 188 (0.64) 52 (0.93) 2.455×10−5 7.19 (2.53–20.44) 113 (0.93) 4.094×10−9 6.95 (3.38–14.27)
G 104 (0.36) 4 (0.07)     9 (0.07)    
Genotype
TT 64 (0.44) 24 (0.86) 4.906×10-5* 7.69 (2.54–23.28)* 56 (0.93) 1.840×10-10* 14.35 (5.43–37.91)*
GT 60 (0.41) 4 (0.14)     1 (0.02)    
GG 22 (0.15) 0 (0.04)     4 (0.07)    
rs3825942
Allele
G 261 (0.89) 55 (0.98) 0.036 6.53 (0.87–48.87) 120 (0.98) 0.002 7.13 (1.68–30.26)
A 31 (0.11) 1 (0.02)     2 (0.02)    
Genotype
GG 116 (0.80) 27 (0.96) 0.032* 6.98 (0.91–53.48)* 59 (0.97) 0.002* 7.63 (1.76–33.03)*
GA 27 (0.18) 1 (0.04)     2 (0.03)    
AA 3 (0.02) 0 (0.00)     0 (0.00)    
rs2165241
Allele
C 265 (0.91) 56 (1.00) 0.018 1.10 (1.06–1.14) 119 (0.98) 0.015 4.04 (1.20–13.58)
T 27 (0.09) 0 (0.00)     3 (0.02)    
Genotype
CC 122 (0.84) 28 (1.00) 0.021* 1.20 (1.11–1.29)* 59 (0.96) 0.009* 5.80 (1.33–25.38)*
CT 21 (0.14) 0 (0.00)     1 (0.02)    
TT 3 (0.02) 0 (0.00)     1 (0.02)    

SNP, single nucleotide polymorphism; XFS, Exfoliation syndrome; XFG, Exfoliation glaucoma; OR, odds ratio. The asterisks (*) indicate the p values and OR ratios derived from comparison of the specific genotype with all of the others, i.e., TT versus GT+GG at rs1048661, GG versus GA+AA at rs3825942, CC versus CT+TT at rs2165241.

Sagong, Mol Vis 2011; 17:2808-2817. http://www.molvis.org/molvis/v17/a305

©2011 Molecular Vision http://www.molvis.org/molvis/

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