Molecular Vision: Tanaka, Mol Vis 2011; 17:2751-2758. Table 2

Table 2. Genotype and allele distributions in AMD patients and control group

Susceptibility genotype	Total AMD patients			nAMD			PCV			RAP			Control
Susceptibility genotype	number	%	p value	number	%	p value	number	%	p-value	number	%	p-value	number	%
rs800292 (CFH) Genotype
G/G	386	56.4	p<0.0001*	147	58.1	p<0.0001*	210	55.1	p<0.0001*	29	56.9	0.011*	100	36.1
G/A	263	38.4		93	36.8		150	39.4		20	39.2		141	50.9
A/A	36	5.3		13	5.1		21	5.5		2	3.9		36	1.3
G/G	386	56.4	p<0.0001*	147	58.1	p<0.0001*	210	55.1	p<0.0001*	29	56.9	0.005*	100	36.1
GA/AA	299	43.6		106	41.9		171	44.9		22	43.1		177	63.9
AA	36	5.3	p<0.0001*	13	5.1	0.002*	21	5.5	0.0008*	2	3.9	0.063	36	1.3
*GA/GG*	649	94.7		240	94.9		360	94.5		49	96.1		241	8.7
rs800292 (CFH) Allele
G	1035	75.5	p<0.0001*	387	76.5	p<0.0001*	570	74.8	p<0.0001*	78	76.5	0.004*	341	61.6
A	335	24.5		119	23.5		192	25.2		24	23.5		213	38.4
rs10490924 (ARMS2) Genotype
G/G	142	20.7	p<0.0001*	46	18.2	p<0.0001*	94	24.7	p<0.0001*	2	3.9	p<0.0001*	99	35.7
G/T	253	36.9		81	32.0		162	42.5		10	19.6		142	51.3
T/T	290	42.3		126	49.8		125	32.8		39	76.5		36	1.3
GG	142	20.7	p<0.0001*	46	18.2	p<0.0001*	94	24.7	0.002*	2	3.9	p<0.0001*	99	35.7
GT+TT	543	79.3		207	81.8		287	0.753		49	0.961		178	64.3
TT	290	42.3	p<0.0001*	126	49.8	p<0.0001*	125	32.8	p<0.0001*	39	76.5	p<0.0001*	36	13.0
*GT+GG*	395	57.7		127	50.2		256	67.2		12	23.5		241	87.0
rs10490924 (ARMS2) Allele
G	537	39.2	p<0.0001*	173	34.2	p<0.0001*	350	45.9	p<0.0001*	14	13.7	p<0.0001*	340	61.4
T	833	60.8		333	65.8		412	54.1		88	86.3		214	38.6
rs2301995 (ELN) Genotype
C/C	457	66.7	0.037*	181	71.5	0.013*	239	62.7	0.237	37	72.5	0.176	165	59.6
C/T	207	30.2		64	25.3		130	34.1		13	25.5		96	34.7
T/T	21	3.1		8	3.2		12	3.1		1	2		16	5.7
CC	457	66.7	0.035*	181	71.5	0.004*	239	62.7	0.41	37	72.5	0.08	165	59.6
CT+TT	228	33.3		72	28.5		142	37.3		14	27.5		112	40.4
TT	21	3.1	0.047*	8	3.2	0.148	12	3.1	0.099	1	2	0.259	16	5.8
*CT+CC*	664	96.9		245	96.8		369	96.9		50	9.8		261	94.2
rs2301995 (ELN) Allele
C	1121	81.8	0.013*	426	84.2	0.003*	608	79.8	0.206	87	85.3	0.059	426	76.9
T	249	18.2		80	15.8		154	20.2		15	14.7		128	23.1
rs1801133 (MTHFR) Genotype
C/C	250	36.5	0.089	110	43.5	0.002*	123	32.3	0.692	17	33.3	0.819	81	29.2
C/T	330	48.2		105	41.5		198	52.0		27	52.9		152	54.9
T/T	105	15.3		38	15.0		60	15.7		7	13.7		44	15.9
CC	250	36.5	0.032*	110	43.5	0.001*	123	32.3	0.404	17	33.3	0.558	81	29.2
CT+TT	435	63.5		143	56.5		258	67.7		34	66.7		196	70.8
TT	105	15.3	0.829	38	15.0	0.783	60	15.7	0.962	7	13.7	0.696	44	15.9
*CT+CC*	580	84.7		215	85.0		321	84.3		44	86.3		233	84.1
rs1801133 (MTHFR) Allele
C	830	60.6	0.114	325	64.2	0.012*	444	58.3	0.564	61	59.8	0.558	314	56.7
T	540	39.4		181	35.8		318	41.7		41	40.2		240	43.3

Abbreviations: AMD represents age-related macular degeneration nAMD represents neovascular age-related macular degeneration PCV represents polypoidal choroidal vasculopathy RAP represents retinal angiomatous proliferation. p-values for the comparison between cases and controls. p-values for genotypes were calculated by Fisher's exact test. *p<0.05. p-values for multiple comparison. Bold font indicate dominant model and bold italic font indicate recessive models.