Figure 1. Schematic presentation of epithelial cell adhesion molecule conjugated to paclitaxel-loaded nanoparticles. The free carboxyl
groups of poly(lactic-co-glycolic acid) (PLGA) are covalently conjugated to amine groups of antibody through ethyl(dimethylaminopropyl)
carbodiimide (EDC)/N-Hydroxysuccinimide (NHS) chemistry. Abbreviations: COOH represents carboxylic functional group; NH2
represents amine functional group; CO NH represents amide functional group.