Figure 5. Model for zebularine inhibition of TGFβ2-induced LEC-myofibroblast transdifferentiation. MeCP2 plays an important role in TGFβ-induced, LEC-myofibroblast transdifferentiation, which is an event marked by α-SMA expression. Zebularine inhibited not only MeCP2 but also TGFβ-induced α-SMA expression. Therefore, zebularine could potentially prevent PCO formation. LEC=lens epithelial cells; IOL=intra ocular lens.