Figure 1. Confocal images of Ctns^-\- mouse cornea. Confocal images of the same Ctns^−/− cornea over time at 3 months (A), 6 months (B), 8 months (C), and 10 months of age (D). Each panel shows a xy (upper) slice through a 3D stack. Cystine crystals were identified as small, 20 µm long, needle-like crystals in the peripheral and central cornea. Note that cystine crystals increase progressively in quantity up to 8 months of age (A, B, and C), but at 10 months, the cornea scarred and showed increased opacity.