Table 2 of De Bonis, Mol Vis 2011; 17:2482-2494.

Table 2. In silico analysis of novel VSX1 and SPARC variants.


Gene		 Protein
alteration		 Polyphen analysis
(PSIC score)		 SIFT analysis
(Score)
Prediction
VSX1 p.G239R 2.172 <0.05 Probably damaging/deleterious
SPARC p.E63K 0.63 0.13 Benign/tolerated
SPARC p.M92I 2.023 0.45 Probably damaging/tolerated
SPARC p.D219E 0.827 0.16 Benign/tolerated

The prediction of functional impact of missense changes identified was performed using two homology based programs PolyPhen (Polymorphism Phenotyping) [37] and SIFT (Sorting Intolerant From Tolerant) [38] analysis tool. PSIC: (Position Specific Independent Counts).

De Bonis, Mol Vis 2011; 17:2482-2494. http://www.molvis.org/molvis/v17/a269

©2011 Molecular Vision http://www.molvis.org/molvis/

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