Figure 5. Genetic network co-expression graphs. A: Genetic coexpression network generated from genes correlated with wildtype Tyrp1 shows that the expression level of Tyrp1 was directly linked to all nodes in the network with an r value of ≥0.5. Moreover 94% of the genes function in mesenchyme development and/or melanin/pigment production. B: A similar network generated using the same 17 genes and expression levels from the mutant database indicates that the expression of Tyrp1 is correlated with only six genes in the network and the tight cohesive nature of the network is lost. C: Genetic coexpression network generated from genes correlated with mutant Tyrp1 shows that the expression level of mutant Tyrp1 was directly linked to only six nodes at r≥0.7. The remaining associations occurred through intermediate links. Only 8% of the genes in the network function in melanin/pigmentation pathways and only 6% function in mesenchyme development, the two top biologic function categories associated with wildtype Tyrp1. ●=melanin/pigmentation pathway; ■=mesenchyme development; ▲=other biologic function. Each transcript is shown as a node and Pearson correlation coefficient values are indicated as lines between nodes. Bold and thin lines reflect coefficients of 1.0–0.7 and 0.7–0.5 respectively. Red/orange and blue/green colors indicate positive and negative correlation coefficients, respectively.