Table 3 of Rydzanicz, Mol Vis 2011; 17:2428-2439.

Table 3. Family-based association test analyses (FBAT) and pedigree disequilibrium test (PDT) analyses of the IGF-1 gene SNPs rs6214, rs2946834, and rs10860860.

High-Grade Myopia
    FBAT  
    additive dominant recesive PDT
SNP Allele Z p Z p Z p Z p
rs10860860 T −0.781 0.434947 −0.946 0.344327 −0.137 0.890758 −1.068 0.2855
  A 0.781 0.434947 0.137 0.890758 0.946 0.344327 1.068 0.2855
rs2946834 T 0.899 0.368809 0.454 0.649731 1.044 0.296272 0.697 0.4855
  C −0.899 0.368809 −1.044 0.296272 −0.454 0.649731 −0.697 0.4855
rs6214 A −0.052 0.958800 0.234 0.815084 −0.412 0.680280 −0.688 0.4913
  G 0.052 0.958800 0.412 0.680280 −0.234 0.815084 0.688 0.4913
rs10860860/ rs6214 AG −0.347 0.728871 0.340 0.733820 −0.807 0.419469 - -
  TA −0.964 0.335015 −0.812 0.416977 - - - -
  AA 1.345 0.178669 1.606 0.108337 - - - -
  TG −0.003 0.997942 0.308 0.758358 - - - -
rs10860860/ rs2946834 AC −0.016 0.987072 −0.886 0.375848 0.760 0.447395 - -
  TT 0.667 0.504478 0.695 0.487210 - - - -
  TC −2.331 0.019747 −2.723 0.006470 - - - -
  AT 1.898 0.057721 1.898 0.057721 - - - -
rs2946834/ rs6214 CG −1.472 0.141034 −1.464 0.143106 −0.662 0.508095 - -
  CA −0.364 0.715703 −0.906 0.364933 - - - -
  TG 1.172 0.241160 1.358 0.174527 - - - -
  TA 1.433 0.151778 1.433 0.151778 - - - -
rs10860860/ rs2946834/ rs6214 ACG −1.467 0.142408 −1.425 0.154041 −0.698 0.484867 - -
  TCA −2.145 0.031928 −2.528 0.011472 - - - -
  ACA 1.743 0.081412 1.781 0.074903 - - - -
  ATG 1.449 0.147280 1.449 0.147280 - - - -
  TTA 0.830 0.406764 0.830 0.406764 - - - -
  TTG 0.438 0.661696 0.826 0.409048 - - - -
  ATA - - - - - - - -
  TCG - - - - - - - -
Any Myopia
    FBAT    
    additive dominant recesive PDT
SNP Allele Z p Z p Z p Z p
rs10860860 T −1.243 0.213893 −0.636 0.525020 −1.423 0.154872 −1.572 0.1159
  A 1.243 0.213893 1.423 0.154872 0.636 0.525020 1.572 0.1159
rs2946834 T −0.757 0.449004 −0.850 0.395113 −0.199 0.842542 −0.983 0.3258
  C 0.757 0.449004 0.199 0.842542 0.850 0.395113 0.983 0.3258
rs6214 A −0.346 0.729034 0.407 0.684086 −1.063 0.287596 −0.567 0.5708
  G 0.346 0.729034 1.063 0.287596 −0.407 0.684086 0.567 0.5708
rs10860860/ rs6214 AG 0.618 0.536845 1.353 0.176003 −0.393 0.694038 - -
  TA −0.769 0.441736 −0.362 0.717451 - - - -
  AA 0.794 0.427175 1.252 0.210729 - - - -
  TG −1.093 0.274437 −0.829 0.407052 - - - -
rs10860860/ rs2946834 AC 0.801 0.423129 0.813 0.416233 0.471 0.637682 - -
  TT −0.737 0.460854 −0.432 0.665463 - - - -
  TC −0.973 0.330541 −1.256 0.209270 - - - -
  AT 1.211 0.226036 1.405 0.160003 - - - -
rs2946834/ rs6214 CG −0.672 0.501768 −0.81 0.417700 −0.201 0.840646 - -
  TG 0.276 0.782902 −0.421 0.673876 - - - -
  CA 0.526 0.59913 0.88 0.379065 - - - -
  TA 0.1 0.920244 0.325 0.745094 - - - -
rs10860860/ rs2946834/ rs6214 ACG −0.270 0.786807 −0.552 0.580836 0.162 0.871179 - -
  TCA −0.539 0.590146 −0.902 0.367010 - - - -
  ACA 1.245 0.213008 1.122 0.261914 - - - -
  ATG 1.027 0.304204 1.251 0.211033 - - - -
  TTA −0.385 0.700077 −0.179 0.857572 - - - -
  TTG −0.474 0.635663 −0.111 0.911560 - - - -
  ATA - - - - - - - -
  TCG - - - - - - - -

Rydzanicz, Mol Vis 2011; 17:2428-2439. http://www.molvis.org/molvis/v17/a264

©2011 Molecular Vision http://www.molvis.org/molvis/

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