Table 2 of
Rydzanicz, Mol Vis 2011; 17:2428-2439. Table 2 of
Rydzanicz, Mol Vis 2011; 17:2428-2439.
Table 2. Genotype distribution and allele frequency of IGF-1 gene SNPs rs6214, rs10860860, and rs2946834.
| High-grade myopia | Any myopia | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Affected | Unaffected | Unknown | Affected | Unaffected | Unknown | Population group | |||||||||
| SNP | SNP genotype/allele | n | % | n | % | n | % | n | % | n | % | n | % | n | % |
| rs6214 | GG | 51 | 40.1 | 54 | 36.5 | 13 | 41.9 | 82 | 39.6 | 27 | 34.6 | 9 | 42.9 | 209 | 38.5 |
| GA | 59 | 46.5 | 78 | 52.7 | 13 | 41.9 | 98 | 47.3 | 43 | 55.1 | 9 | 42.9 | 264 | 48.6 | |
| AA | 17 | 13.4 | 16 | 10.2 | 5 | 16.2 | 27 | 13.1 | 8 | 10.3 | 3 | 14.2 | 70 | 12.9 | |
| G | 161 | 63.4 | 186 | 62.8 | 39 | 62.9 | 262 | 63.3 | 97 | 62.2 | 27 | 64.3 | 682 | 62.8 | |
| A | 93 | 36.6 | 110 | 37.2 | 23 | 37.1 | 152 | 36.7 | 59 | 37.8 | 15 | 35.7 | 404 | 37.2 | |
| rs10860860 | AA | 57 | 44.9 | 60 | 40.5 | 15 | 48.4 | 96 | 46.4 | 23 | 29.5 | 13 | 61.9 | 248 | 45.7 |
| AT | 54 | 42.5 | 75 | 50.7 | 14 | 45.2 | 88 | 42.5 | 48 | 61.5 | 7 | 33.3 | 251 | 46.2 | |
| TT | 16 | 12.6 | 13 | 8.8 | 2 | 6.4 | 23 | 11.1 | 7 | 9.0 | 1 | 4.8 | 44 | 8.1 | |
| A | 168 | 66.1 | 195 | 65.9 | 44 | 71.0 | 280 | 67.6 | 94 | 60.3 | 33 | 78.6 | 747 | 68.8 | |
| T | 86 | 33.9 | 101 | 34.1 | 18 | 29.0 | 134 | 32.4 | 62 | 39.7 | 9 | 21.4 | 339 | 31.2 | |
| rs2946834 | CC | 61 | 48.8 | 72 | 49.0 | 14 | 45.2 | 109 | 53.4 | 29 | 37.2 | 9 | 42.9 | - | - |
| CT | 48 | 38.4 | 61 | 41.5 | 14 | 45.2 | 78 | 38.2 | 37 | 47.4 | 8 | 38.1 | - | - | |
| TT | 16 | 12.8 | 14 | 9.5 | 3 | 9.7 | 17 | 8.3 | 12 | 15.4 | 4 | 19.0 | - | - | |
| C | 170 | 68 | 205 | 69.7 | 42 | 67.7 | 296 | 72.5 | 95 | 60.9 | 26 | 61.9 | - | - | |
| T | 80 | 32 | 89 | 30.3 | 20 | 32.3 | 112 | 27.5 | 61 | 39.1 | 16 | 38.1 | - | - | |
| rs6214/ rs10860860 | GG / AA | 35 | 27.6 | 40 | 27.0 | 9 | 29.0 | 61 | 29.5 | 15 | 19.2 | 8 | 38.1 | 154 | 28.4 |
| GG / AT | 13 | 10.2 | 13 | 8.8 | 4 | 12.9 | 18 | 8.7 | 11 | 14.1 | 1 | 4.8 | 53 | 9.8 | |
| GG / TT | 3 | 2.4 | 1 | 0.7 | 0 | 0.0 | 3 | 1.4 | 1 | 1.3 | 0 | 0 | 2 | 0.4 | |
| GA / AA | 19 | 14.9 | 19 | 12.8 | 5 | 16.1 | 31 | 15.0 | 7 | 9.0 | 5 | 23.8 | 81 | 14.9 | |
| GA / AT | 34 | 26.8 | 55 | 37.2 | 8 | 25.8 | 60 | 29.0 | 33 | 42.3 | 4 | 19.0 | 158 | 29.0 | |
| GA / TT | 6 | 4.7 | 4 | 2.7 | 0 | 0.0 | 7 | 3.4 | 3 | 3.8 | 0 | 0 | 25 | 4.6 | |
| AA / AA | 3 | 2.4 | 1 | 0.7 | 1 | 3.2 | 4 | 1.9 | 1 | 1.3 | 0 | 0 | 13 | 2.4 | |
| AA / AT | 7 | 5.5 | 7 | 4.7 | 2 | 6.5 | 10 | 4.8 | 4 | 5.2 | 2 | 9.5 | 40 | 7.4 | |
| AA / TT | 7 | 5.5 | 8 | 5.4 | 2 | 6.5 | 13 | 6.3 | 3 | 3.8 | 1 | 4.8 | 17 | 3.1 | |
| rs2946834/ rs6214 | CT / GG | 18 | 14.4 | 18 | 12.2 | 6 | 19.4 | 28 | 13.7 | 12 | 15.4 | 2 | 9.5 | - | - |
| CT / GA | 24 | 19.2 | 32 | 21.8 | 7 | 22.6 | 41 | 20.1 | 18 | 23.1 | 4 | 19.0 | - | - | |
| CC / AA | 9 | 7.2 | 5 | 3.4 | 4 | 12.9 | 16 | 7.8 | 1 | 1.3 | 1 | 4.8 | - | - | |
| TT / AA | 2 | 1.6 | 0 | 0.0 | 0 | 0.0 | 2 | 1.0 | 0 | 0.0 | 0 | 0.0 | - | - | |
| CT / AA | 6 | 4.8 | 11 | 7.5 | 1 | 3.2 | 9 | 4.4 | 7 | 9.0 | 2 | 9.5 | - | - | |
| CC / GA | 27 | 21.6 | 37 | 25.2 | 5 | 16.1 | 48 | 23.5 | 18 | 23.1 | 3 | 14.3 | - | - | |
| CC / GG | 25 | 20 | 30 | 20.4 | 5 | 16.1 | 45 | 22.1 | 10 | 12.8 | 5 | 23.8 | - | - | |
| TT / GA | 7 | 5.6 | 9 | 6.1 | 1 | 3.2 | 8 | 3.9 | 7 | 9.0 | 2 | 9.5 | - | - | |
| TT / GG | 7 | 5.6 | 5 | 3.4 | 2 | 6.5 | 7 | 3.4 | 5 | 6.4 | 2 | 9.5 | - | - | |
| rs10860860/ rs2946834 | AT / CT | 29 | 23.2 | 42 | 28.6 | 5 | 16.1 | 43 | 21.1 | 29 | 37.2 | 4 | 19.0 | - | - |
| TT / TT | 8 | 6.4 | 3 | 2.0 | 0 | 0.0 | 8 | 3.9 | 3 | 3.8 | 0 | 0.0 | - | - | |
| TT / CT | 5 | 4 | 7 | 4.8 | 1 | 3.2 | 9 | 4.4 | 4 | 5.1 | 0 | 0.0 | - | - | |
| AT / TT | 7 | 5.6 | 6 | 4.1 | 3 | 9.7 | 8 | 3.9 | 6 | 7.7 | 2 | 9.5 | - | - | |
| AA / CC | 42 | 33.6 | 42 | 28.6 | 7 | 22.6 | 68 | 33.3 | 16 | 20.5 | 7 | 33.3 | - | - | |
| AA / TT | 1 | 0.8 | 5 | 3.4 | 0 | 0.0 | 1 | 0.5 | 3 | 3.8 | 2 | 9.5 | - | - | |
| AA / CT | 14 | 11.2 | 12 | 8.2 | 8 | 25.8 | 26 | 12.7 | 4 | 5.1 | 4 | 19.0 | - | - | |
| AT / CC | 16 | 12.8 | 27 | 18.4 | 6 | 19.4 | 35 | 17.2 | 13 | 16.7 | 1 | 4.8 | - | - | |
| TT / CC | 3 | 2.4 | 3 | 2.0 | 1 | 3.2 | 6 | 2.9 | 0 | 0.0 | 1 | 4.8 | - | - | |
| rs10860860/ rs2946834/ rs6214 | AA / CC / AA | 3 | 2.4 | 1 | 0.7 | 1 | 3.2 | 4 | 2.0 | 1 | 1.3 | 0 | 0.0 | - | - |
| AA / CC / GA | 15 | 12.0 | 13 | 8.8 | 1 | 3.2 | 21 | 10.3 | 6 | 7.7 | 2 | 9.5 | - | - | |
| AA / CC / GG | 24 | 19.2 | 28 | 19.0 | 5 | 16.1 | 43 | 21.1 | 9 | 11.5 | 5 | 23.8 | - | - | |
| AA / CT / GA | 4 | 3.2 | 4 | 2.7 | 4 | 12.9 | 10 | 4.9 | 0 | 0.0 | 2 | 9.5 | - | - | |
| AA / CT / GG | 10 | 8.0 | 8 | 5.4 | 4 | 12.9 | 16 | 7.8 | 4 | 5.1 | 2 | 9.5 | - | - | |
| AA / TT / GA | 0 | 0.0 | 2 | 1.4 | 0 | 0.0 | 0 | 0.0 | 1 | 1.3 | 1 | 4.8 | - | - | |
| AA / TT / GG | 1 | 0.8 | 3 | 2.0 | 0 | 0.0 | 1 | 0.5 | 2 | 2.6 | 1 | 4.8 | - | - | |
| AT / CC / AA | 3 | 2.4 | 1 | 0.7 | 2 | 6.5 | 6 | 2.9 | 0 | 0.0 | 0 | 0.0 | - | - | |
| AT / CC / GA | 12 | 9.6 | 24 | 16.3 | 4 | 12.9 | 27 | 13.2 | 12 | 15.4 | 1 | 4.8 | - | - | |
| AT / CC / GG | 1 | 0.8 | 2 | 1.4 | 0 | 0.0 | 2 | 1.0 | 1 | 1.3 | 0 | 0.0 | - | - | |
| AT / CT / AA | 3 | 2.4 | 6 | 4.1 | 0 | 0.0 | 3 | 1.5 | 4 | 5.1 | 2 | 9.5 | - | - | |
| AT / CT / GA | 18 | 14.4 | 26 | 17.7 | 3 | 9.7 | 28 | 13.7 | 17 | 21.8 | 2 | 9.5 | - | - | |
| AT / CT / GG | 8 | 6.4 | 10 | 6.8 | 2 | 6.5 | 12 | 5.9 | 8 | 10.3 | 0 | 0.0 | - | - | |
| AT / TT / AA | 1 | 0.8 | 0 | 0.0 | 0 | 0.0 | 1 | 0.5 | 0 | 0.0 | 0 | 0.0 | - | - | |
| AT / TT / GA | 3 | 2.4 | 5 | 3.4 | 1 | 3.2 | 4 | 2.0 | 4 | 5.1 | 1 | 4.8 | - | - | |
| AT / TT / GG | 3 | 2.4 | 1 | 0.7 | 2 | 6.5 | 3 | 1.5 | 2 | 2.6 | 1 | 4.8 | - | - | |
| TT / CC / AA | 3 | 2.4 | 3 | 2.0 | 1 | 3.2 | 6 | 2.9 | 0 | 0.0 | 0 | 0.0 | - | - | |
| TT / CT / AA | 3 | 2.4 | 5 | 3.4 | 1 | 3.2 | 6 | 2.9 | 3 | 3.8 | 0 | 0.0 | - | - | |
| TT / CT / GA | 2 | 1.6 | 2 | 1.4 | 0 | 0.0 | 3 | 1.5 | 1 | 1.3 | 0 | 0.0 | - | - | |
| TT / TT / AA | 1 | 0.8 | 0 | 0.0 | 0 | 0.0 | 1 | 0.5 | 0 | 0.0 | 1 | 4.8 | - | - | |
| TT / TT / GA | 4 | 3.2 | 2 | 1.4 | 0 | 0.0 | 4 | 2.0 | 2 | 2.6 | 0 | 0.0 | - | - | |
| TT / TT / GG | 3 | 2.4 | 1 | 0.7 | 0 | 0.0 | 3 | 1.5 | 1 | 1.3 | 0 | 0.0 | - | - | |