Figure 1. Example of genotype distribution of SNPs rs10860860, rs2946834, and rs6214 in the IGF-1 gene. A: Pedigree of HM-14 family. Filled symbols: individuals with high myopia; open symbols: unaffected individuals; symbols with a question mark: individuals with an unknown disease status; an arrow indicates a proband. Detailed clinical findings in family HM-14 are shown in Appendix 3. B: RFLP analysis of SNP rs10860860 and C: RFLP analysis of SNP rs6214. Line M: DNA ladder 25–700 bp, remaining lines: numbers of genotyped individuals according to the pedigree HM-14. Below, genotypes are shown. D: Partial sequence chromatograms showing rs10860860, E: rs6214, and F: rs2946834 genotypes, respectively. Black squares indicate SNP alleles.