Table 2 of
Chen, Mol Vis 2011; 17:2297-2310. Table 2 of
Chen, Mol Vis 2011; 17:2297-2310.
Table 2. Association between single nucleotide polymorphisms in sex steroidogenesis enzyme genes and high myopia risk and Hardy–Weinberg equilibrium test.
| High myopia | HWE | Association results | ||||||
|---|---|---|---|---|---|---|---|---|
| Gene | SNP | Case (n=283) | Control (n=280) | p-value | p-value | OR (95% CI) | p-value* | OR (95% CI)* |
| CYP17A1 | rs743572 | 1.000 | 0.608 | 0.351 | ||||
| GG | 82 | 92 | 1.00 (reference) | 1.00 (reference) | ||||
| GA | 147 | 137 | 1.20 (0.83–1.76) | 1.33 (0.90–1.95) | ||||
| AA | 54 | 51 | 1.19 (0.73–1.93) | 1.26 (0.77–2.06) | ||||
| HSD3B1 | rs6203 | 0.590 | 0.939 | 0.887 | ||||
| TT | 115 | 113 | 1.00 (reference) | 1.00 (reference) | ||||
| TC | 138 | 133 | 1.02 (0.72–1.45) | 1.00 (0.70–1.44) | ||||
| CC | 30 | 34 | 0.87 (0.50–1.51) | 0.89 (0.50–1.57) | ||||
| HSD3B1 | rs1047303 | 0.620 | 0.922 | 0.808 | ||||
| AA | 236 | 239 | 1.00 (reference) | 1.00 (reference) | ||||
| AC | 46 | 40 | 1.16 (0.74–1.85) | 1.18 (0.73–1.89) | ||||
| CC | 1 | 1 | 1.01 (0.06–16.29) | 0.82 (0.05–13.34) | ||||
| HSD17B1 | rs605059 | 0.359 | 0.809 | 0.821 | ||||
| GG | 87 | 76 | 1.00 (reference) | 1.00 (reference) | ||||
| GA | 140 | 147 | 0.83 (0.57–1.22) | 0.88 (0.60–1.31) | ||||
| AA | 56 | 57 | 0.86 (0.53–1.39) | 0.89 (0.55–1.45) | ||||
| SRD5A2 | rs523349 | 0.386 | 0.776 | 0.596 | ||||
| GG | 97 | 99 | 1.00 (reference) | 1.00 (reference) | ||||
| GC | 141 | 129 | 1.12 (0.77–1.61) | 1.17 (0.81–1.71) | ||||
| CC | 45 | 52 | 0.88 (0.54–1.44) | 0.91 (0.55–1.49) | ||||
| CYP19A1 | rs10046 | 0.983 | 0.799 | 0.678 | ||||
| AA | 80 | 87 | 1.00 (reference) | 1.00 (reference) | ||||
| AG | 151 | 138 | 1.19 (0.81–1.74) | 1.22 (0.83–1.80) | ||||
| GG | 52 | 55 | 1.03 (0.63–1.67) | 1.22 (0.66–1.84) | ||||