Figure 1. Linkage analysis of autosomal dominant cataract segregating in a 5-generation Caucasian American pedigree (family Sh). A: Pedigree and haplotype analysis showing segregation of 3 microsatellite markers on chromosome 13q listed in descending order from the centromere (13p-tel). Squares and circles denote males and females respectively. Filled symbols denote affected status. B: Ideogram of chromosome 13 showing the cytogenetic location of the cataract locus.