Figure 3. Conservation alignments of protein orthologs for 4 of the 5 novel mutations. The regions with p.[R117H,Y118del] in CRYAA, p.R69C in CRYAB, and p.D26G in CRYGS are highly conserved, while the p.A36P in CRYGD is not conserved (only 6 of the 8 orthologs available for CRYGD).