Molecular Vision: Sun, Mol Vis 2011; 17:2191-2196. Table 2

Table 2. Pharmacokinetic parameters in ocular tissues after topical administration of 0.5% pirfenidone solution in rabbit eyes.

Pharmacokinetic parameters	Cornea	Conjunctiva	Sclera	Aqueous humor	Vitreous
Tmax (min)	8	8	8	10	15
Cmax (mg/l)*	9.64*	9.62*	2.13*	34.88	0.52
AUC0-t (min•mg/l)	282.03	197.70	46.65	919.84	15.17
AUC0-∞ (min•mg/l)	284.58	206.91	49.34	925.99	19.88
T1/2 (min)	18.26	34.16	39.48	15.71	70.91
Lambda_z (1/min•10^–1)	0.38	0.20	0.18	0.44	0.10

Cmax=observed maximum concentration; Tmax=time to Cmax; AUC0-t=area under the curve until the last measurable concentration; AUC0-∞=area under the curve from 0 to infinity; T1/2=Elimination half-life; and Lambda_z=First order rate constant associated with the terminal (log-linear) portion of the curve. *The concentration of pirfenidone in cornea, conjunctiva, and sclera is determined as milligrams per gram of tissue.