Table 1 of
Sun, Mol Vis 2011; 17:2191-2196. Table 1 of
Sun, Mol Vis 2011; 17:2191-2196.
Table 1. Ocular tissue concentrations of 0.5% pirfenidone solution after its topical administration in rabbit eyes.
Time (min) |
Cornea (mg/g; Mean±SD) |
Conjunctiva (mg/g; Mean±SD) |
Sclera (mg/g; Mean±SD) |
Aqueous (mg/l; Mean±SD) |
Vitreous (mg/l; Mean±SD) |
|---|---|---|---|---|---|
| 2 | 7.53±0.35 | 8.87±1.17 | 1.34±0.05 | 19.59±7.28 | 0.30±0.01 |
| 5 | 7.02±0.96 | 9.14±1.32 | 1.00±0.53 | 20.39±6.54 | 0.47±0.17 |
| 8 | 9.64±0.99 | 9.62±0.81 | 2.13±1.02 | 30.29±9.69 | 0.50±0.01 |
| 10 | 8.25±0.28 | 5.63±1.40 | 0.69±0.35 | 34.88±11.10 | 0.36±0.12 |
| 15 | 8.32±1.06 | 6.43±1.61 | 1.04±0.34 | 16.92±1.18 | 0.51±0.02 |
| 20 | 4.00±1.47 | 1.46±0.44 | 0.36±0.13 | 15.02±6.74 | 0.14±0.04 |
| 30 | 2.26±1.03 | 0.98±0.31 | 0.25±0.16 | 10.79±3.72 | 0.12±0.03 |
| 60 | 1.03±0.33 | 0.73±0.32 | 0.14±0.10 | 4.06±2.03 | 0.08±0.02 |
| 90 | 1.34±0.25 | 0.57±0.17 | 0.50±0.09 | 2.43±0.17 | 0.05±0.00 |
| 120 | 0.10±0.04 | 0.19±0.11 | 0.05±0.03 | 0.271±0.16 | 0.05±0.01 |