Figure 4. Haplotype analysis of FEVR genes. Only a subset of the pedigree is displayed; shaded individuals are those whose phenotype suggests FEVR. EVR2 (Norrin) is excluded by the pedigree structure showing male to male transmission. For each locus examined, the affected individuals do not share the same haplotype, indicating that the causative gene does not reside in this region of the chromosomal. A: EVR1 (FZD4); B: EVR3 11p13-p12; C: EVR4 (LRP5).