Table 3 of Nieto-Miguel, Mol Vis 2011; 17:2102-2117.

Table 3. Ingenuity canonical pathways that were most significantly affected.

Ingenuity Canonical Pathways -Log(B-H P-value)* Ratio Molecules
Wnt/β2-catenin Signaling 8.54E+00 6.67E-02 SOX2, CDH2, GJA1, AXIN1, FRAT1, DVL1, BTRC, FZD1, CCND1, WNT1, APC
Notch Signaling 3.28E+00 9.76E-02 NOTCH2, DLL1, DTX1, JAG1
Cell Cycle: G1/S Checkpoint Regulation 2.58E+00 6.78E-02 CCNE1, HDAC2, BTRC, CCND1
Actin Cytoskeleton Signaling 1.49E+00 2.20E-02 FGF4, CDC42, ACTC1, APC, FGF1
Aryl Hydrocarbon Receptor Signaling 1.34E+00 2.58E-02 CCNA2, CCNE1, ALDH1A1, CCND1
Clathrin-mediated Endocytosis 1.34E+00 2.42E-02 FGF4, CDC42, ACTC1, FGF1
Axonal Guidance Signaling 1.34E+00 1.52E-02 CDC42, BMP2, FZD1, WNT1, BMP1
FGF Signaling 1.27E+00 3.49E-02 FGF4, FGFR1, FGF1
Ephrin Receptor Signaling 1.27E+00 2.07E-02 CDC42, AXIN1, CXCL12, FGF1
T Cell Receptor Signaling 1.11E+00 2.78E-02 CD8A, CD3D, CD8B
Cell Cycle: G2/M DNA Damage Checkpoint Regulation 1.07E+00 4.65E-02 BTRC, CDC2
Tight Junction Signaling 8.86E-01 1.83E-02 CDC42, ACTC1, PARD6A
NF-Κ°B Signaling 8.86E-01 2.08E-02 HDAC2, BMP2, BTRC
Calcium-induced T Lymphocyte Apoptosis 8.21E-01 3.28E-02 HDAC2, CD3D
Leukocyte Extravasation Signaling 7.08E-01 1.55E-02 CDC42, CXCL12, ACTC1
BMP signaling pathway 7.08E-01 2.50E-02 BMP2, BMP1
Regulation of Actin-based Motility by Rho 7.08E-01 2.17E-02 CDC42, ACTC1
PTEN Signaling 6.12E-01 2.02E-02 CDC42, CCND1
Fcγ3 Receptor-mediated Phagocytosis in Macrophages and Monocytes 5.94E-01 1.92E-02 CDC42, ACTC1
CD28 Signaling in T Helper Cells 4.92E-01 1.65E-02 CDC42, CD3D
Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells 4.92E-01 3.85E-02 CD3D
Glucocorticoid Receptor Signaling 4.92E-01 1.09E-02 HSPA9, BGLAP, CD3D
Hepatic Fibrosis / Hepatic Stellate Cell Activation 4.73E-01 1.48E-02 FGFR1, FGF1
Sonic Hedgehog Signaling 4.34E-01 3.23E-02 CDC2
Ascorbate and Aldarate Metabolism 4.12E-01 1.22E-02 ALDH1A1
Calcium Signaling 3.39E-01 9.71E-03 HDAC2, ACTC1
Retinol Metabolism 3.39E-01 1.56E-02 ALDH1A1
Integrin Signaling 3.39E-01 1.01E-02 CDC42, ACTC1
Huntington’s Disease Signaling 3.39E-01 8.62E-03 HDAC2, HSPA9
Histidine Metabolism 3.39E-01 9.01E-03 ALDH1A1
GM-CSF Signaling 3.39E-01 1.54E-02 CCND1
Activation of IRF by Cytosolic Pattern Recognition Receptors 3.39E-01 1.37E-02 ADAR
Macropinocytosis 3.39E-01 1.43E-02 CDC42
CCR5 Signaling in Macrophages 3.39E-01 1.16E-02 CD3D
Neurotrophin/TRK Signaling 3.39E-01 1.32E-02 CDC42
Caveolar-mediated Endocytosis 3.39E-01 1.25E-02 ACTC1
PXR/RXR Activation 3.39E-01 1.16E-02 ALDH1A1
LPS-stimulated MAPK Signaling 3.39E-01 1.27E-02 CDC42
Bile Acid Biosynthesis 3.39E-01 1.03E-02 ALDH1A1
Chemokine Signaling 3.39E-01 1.30E-02 CXCL12
L2-alanine Metabolism 3.39E-01 1.01E-02 ALDH1A1
VDR/RXR Activation 3.39E-01 1.25E-02 BGLAP
Butanoate Metabolism 3.39E-01 7.75E-03 ALDH1A1
Pyruvate Metabolism 3.39E-01 6.90E-03 ALDH1A1
CTLA4 Signaling in Cytotoxic T Lymphocytes 3.39E-01 1.16E-02 CD3D
TGF-β2 Signaling 3.39E-01 1.16E-02 BMP2
Lysine Degradation 3.39E-01 6.94E-03 ALDH1A1
Propanoate Metabolism 3.39E-01 7.94E-03 ALDH1A1
Apoptosis Signaling 3.39E-01 1.06E-02 CDC2
p53 Signaling 3.39E-01 1.15E-02 CCND1
VEGF Signaling 3.39E-01 1.05E-02 ACTC1
SAPK/JNK Signaling 3.39E-01 1.08E-02 CDC42
Glycerolipid Metabolism 3.39E-01 6.90E-03 ALDH1A1
Valine, Leucine and Isoleucine Degradation 3.39E-01 9.35E-03 ALDH1A1
FXR/RXR Activation 3.39E-01 1.00E-02 FOXA2
Glycolysis/Gluconeogenesis 3.33E-01 7.09E-03 ALDH1A1
Nicotinate and Nicotinamide Metabolism 3.33E-01 7.75E-03 CDC2
fMLP Signaling in Neutrophils 3.03E-01 8.00E-03 CDC42
Arginine and Proline Metabolism 3.01E-01 5.62E-03 ALDH1A1
PI3K/AKT Signaling 3.00E-01 7.41E-03 CCND1
Protein Ubiquitination Pathway 2.60E-01 4.95E-03 BTRC
Inositol Phosphate Metabolism 2.60E-01 5.78E-03 CDC2
B Cell Receptor Signaling 2.54E-01 6.54E-03 CDC42
CXCR4 Signaling 2.51E-01 6.10E-03 CXCL12
IL-8 Signaling 2.51E-01 5.46E-03 CCND1
Tryptophan Metabolism 2.51E-01 4.20E-03 ALDH1A1
RAR Activation 2.51E-01 5.49E-03 ALDH1A1
Role of NFAT in Regulation of the Immune Response 2.51E-01 5.38E-03 CD3D
Fatty Acid Metabolism 2.51E-01 5.29E-03 ALDH1A1
NRF2-mediated Oxidative Stress Response 2.51E-01 5.46E-03 ACTC1
LPS/IL-1 Mediated Inhibition of RXR Function 2.29E-01 5.05E-03 ALDH1A1