Figure 4. Networks generated by IPA related to drug metabolism, small molecule biochemistry and cell morphology and to cancer, cell cycle, skeletal and muscular disorders. Drug metabolism, small molecule biochemistry and cell morphology network (A), and cancer, cell cycle, skeletal and muscular disorders network (B) generated by IPA. The network contained nodes (gene/gene product) and edges (indicating a relationship between the nodes) showing the cellular/subcellular location as indicated. Function classes of nodes were indicated by shape to represent functional class. Colored molecules represented genes that appeared in the data set studied. Red and green molecules were upregulated and down-regulated, respectively, in limbal epithelial cells. Gray molecules did not meet the user defined cutoff of 2. White indicated the molecule was added from the IPKB.