Figure 3. Alignment of MYOC peptide sequences in human and other species. The CLUSTAL W (2.0) computer program was used for multiple alignment of amino acid sequences. The position of mutated amino acids in the PCG patient reported in this study is boxed. Note that the p.L228S and p.E240G mutations occurred at highly conserved positions of the amino acids (filled arrow; p.Leu228, open arrow; p.Glu240).