Figure 1. Pedigree, haplotypes on chromosome 12q and MIP mutation. Pedigree and haplotypes are shown on top. Filled squares (male) or circles (female) represent individuals affected with cerulean cataract. Bars filled with black indicate the chromosomal regions that are derived from the ancestral disease-associated haplotype. Sequence tracing of the MIP mutation is shown at bottom. Arrow indicates the site with double peaks, where a heterozygous T to C variant affects the second nucleotide of the ATG initiation codon for MIP.