Table 2 of Valentincic, Mol Vis 2011; 17:2003-2010.
Inflammatory mediators | Controls (n=10) | IU patients (n=36) | Active disease (n=15) | Quiescent disease (n=21) | CME (n=7) | No CME (n=29) | Systemic therapy (n=10) | No systemic therapy (n=26) | Systemic disease (n=9) | No systemic disease (n=27) |
---|---|---|---|---|---|---|---|---|---|---|
Mean age (yrs) | 40 | 36 | 42 | 32 | 44 | 35 | 43 | 36 | 44 | 34 |
Geometric
mean (pg/ml) Median (pg/ml) Range (pg/ml) p value |
||||||||||
IL-1β (2.0)* | 1.4 1.1 2.2–4.5 | 2.3 2.5 2.2–6.7 | 2.1 2.1 2.2–6.7 | 2.5 2.2 2.2–4.6 | 2.5 2.5 2.2–6.7 | 2.2 2.6 2.2–5.7 | 2.3 2.5 2.2–6.7 | 2.3 2.7 2.2–5.7 | 2.5 4.0 2.2–4.5 | 2.2 3.2 2.2–6.6 |
0.020 | 0.279 | 0.845 | 0.876 | 0.641 | ||||||
IL-6 (0.5) | 3.3 4.8 0.6–31.0 | 27.5 24.5 2.0–433.1 | 66.5 57.3 5.6–433.1 | 14.6 15.4 2.1–160.6 | 86.7 64.4 5.6–433.1 | 20.8 20.7 2.0–294.0 | 40.1 34.6 5.6–358.4 | 23.8 21.8 2.1–433.1 | 32.9 42.6 2.0–295.0 | 25.9 21.5 2.3–433.1 |
0.001 | 0.003 | 0.026 | 0.393 | 0.693 | ||||||
IL-8 (0.4) | 2.6 3.8 0.4–7.9 | 14.2 15.6 1.0–84.0 | 34.0 25.8 9.2–183.9 | 7.6 5.9 1.0–57.1 | 40.4 25.8 15.5–83.9 | 11.0 9.2 1.0–106.7 | 26.2 24.4 3.8–183.9 | 11.2 10.3 1.0–106.7 | 17.6 26.8 2.9–68.4 | 13.2 13.6 1.0–183.9 |
<0.0001 | <0.0001 | 0.012 | 0.074 | 0.565 | ||||||
IL-10 (1.5) | 1.1 2.6 1.7–2.2 | 2.0 2.8 1.7–14.7 | 2.5 3.0 1.7–14.7 | 1.7 2.5 1.7–5.5 | 2.5 2.8 1.7–4.3 | 1.9 2.0 1.7–14.7 | 2.1 2.6 1.7–3.6 | 1.9 2.0 1.7–14.7 | 2.1 2.5 1.7–5.5 | 2.0 2.1 1.7–14.7 |
0.005 | 0.062 | 0.054 | 0.256 | 0.641 | ||||||
TNF-α (2.0) | 2.0 2.8 2.4–3.3 | 2.4 2.6 2.4–5.4 | 2.7 2.8 2.4–5.2 | 2.2 2.8 2.4–5.4 | 3.1 3.3 2.4–5.2 | 2.2 2.7 2.4–5.4 | 3.2 3.0 2.4–5.2 | 2.9 2.6 2.4–5.3 | 2.3 2.7 2.4–5.2 | 2.3 3.0 2.4–5.4 |
0.323 | 0.462 | 0.094 | 0.135 | 0.247 | ||||||
IL-12p70 (1.5) | 1.0 0.9 1.7–2.0 | 2.1 2.7 1.7–5.9 | 2.1 2.5 1.7–5.9 | 2.2 3.0 1.7–4.8 | 2.8 2.5 1.7–5.9 | 2.0 2.8 1.7–4.8 | 2.4 3.0 1.7–5.9 | 2.1 2.5 1.7–4.8 | 2.5 3.0 1.7–4.8 | 2.0 2.5 1.7–5.9 |
0.003 | 0.505 | 0.480 | 0.520 | 0.565 | ||||||
CCL5/RANTES (0.02) | 1.8 1.5 1.1–3.9 | 3.6 2.3 0.0–76.5 | 6.3 3.7 0.5–59.4 | 2.1 2.0 0.0–76.5 | 8.4 8.5 2.0–59.4 | 2.9 2.1 0.0–76.5 | 4.5 5.7 0.0–43.0 | 3.3 2.1 0.5–76.5 | 8.9 8.5 0.5–76.5 | 2.7 2.3 0.0–59.4 |
0.091 | 0.033 | 0.078 | 0.355 | 0.192 | ||||||
CCL3/MIP-1α (4.0) | 3.2 3.1 4.1–9.1 | 4.0 4.9 4.1–15.2 | 4.5 5.3 4.1–8.0 | 3.7 4.8 4.1–15.3 | 3.9 4.2 4.1–8.0 | 4.1 5.0 4.1–15.3 | 4.2 4.7 4.1–8.0 | 4.0 5.2 4.1–15.3 | 5.0 5.0 4.1–15.3 | 3.8 4.8 4.1–8.0 |
0.812 | 0.202 | 0.907 | 0.931 | 0.368 | ||||||
CCL4/MIP-1β (3.0) | 27.9 24.3 19.0–43.8 | 34.6 32.3 16.4–190.9 | 35.5 34.4 16.4–85.0 | 34.0 30.2 16.9–190.4 | 33.8 34.4 16.4–85.0 | 34.8 32.0 16.9–190.4 | 34.5 32.3 16.4–190.4 | 35.1 31.8 18.4–85.0 | 39.7 32.7 16.9–190.4 | 33.1 30.5 16.4–85.0 |
0.350 | 0.657 | 0.876 | 0.821 | 0.720 | ||||||
CCL2/MCP1 (3.0) | 235.9 232.4 140.3–415.5 | 595.7 417.5 143.4–4230.1 | 888.6 846.7 214.6–3270.0 | 447.7 316.9 143.1–4230.1 | 857.4 846.7 222.7–2536.0 | 545.6 361.0 143.1–4230.1 | 767.9 781.0 214.6–3270.0 | 540.3 356.3 143.1–4230.1 | 901.0 959.9 143.1–4230.1 | 519.0 363.9 200.1–3270.0 |
0.003 | 0.033 | 0.236 | 0.320 | 0.157 |