Table 2 of Valentincic, Mol Vis 2011; 17:2003-2010.


Table 2. Aqueous humor cytokine levels in patients with intermediate uveitis and in controls.

Inflammatory mediators Controls (n=10) IU patients (n=36) Active disease (n=15) Quiescent disease (n=21) CME (n=7) No CME (n=29) Systemic therapy (n=10) No systemic therapy (n=26) Systemic disease (n=9) No systemic disease (n=27)
Mean age (yrs) 40 36 42 32 44 35 43 36 44 34
Geometric mean (pg/ml)

Median (pg/ml)

Range (pg/ml)

p value
IL-1β (2.0)* 1.4
1.1
2.2–4.5 2.3
2.5
2.2–6.7 2.1
2.1
2.2–6.7 2.5
2.2
2.2–4.6 2.5
2.5
2.2–6.7 2.2
2.6
2.2–5.7 2.3
2.5
2.2–6.7 2.3
2.7
2.2–5.7 2.5
4.0
2.2–4.5 2.2
3.2
2.2–6.6
  0.020 0.279 0.845 0.876 0.641
IL-6 (0.5) 3.3
4.8
0.6–31.0 27.5
24.5
2.0–433.1 66.5
57.3
5.6–433.1 14.6
15.4
2.1–160.6 86.7
64.4
5.6–433.1 20.8
20.7
2.0–294.0 40.1
34.6
5.6–358.4 23.8
21.8
2.1–433.1 32.9
42.6
2.0–295.0 25.9
21.5
2.3–433.1

0.001 0.003 0.026 0.393 0.693
IL-8 (0.4) 2.6
3.8
0.4–7.9 14.2
15.6
1.0–84.0 34.0
25.8
9.2–183.9 7.6
5.9
1.0–57.1 40.4
25.8
15.5–83.9 11.0
9.2
1.0–106.7 26.2
24.4
3.8–183.9 11.2
10.3
1.0–106.7 17.6
26.8
2.9–68.4 13.2
13.6
1.0–183.9
  <0.0001 <0.0001 0.012 0.074 0.565
IL-10 (1.5) 1.1
2.6
1.7–2.2 2.0
2.8
1.7–14.7 2.5
3.0
1.7–14.7 1.7
2.5
1.7–5.5 2.5
2.8
1.7–4.3 1.9
2.0
1.7–14.7 2.1
2.6
1.7–3.6 1.9
2.0
1.7–14.7 2.1
2.5
1.7–5.5 2.0
2.1
1.7–14.7
  0.005 0.062 0.054 0.256 0.641
TNF-α (2.0) 2.0
2.8
2.4–3.3 2.4
2.6
2.4–5.4 2.7
2.8
2.4–5.2 2.2
2.8
2.4–5.4 3.1
3.3
2.4–5.2 2.2
2.7
2.4–5.4 3.2
3.0
2.4–5.2 2.9
2.6
2.4–5.3 2.3
2.7
2.4–5.2 2.3
3.0
2.4–5.4
  0.323 0.462 0.094 0.135 0.247
IL-12p70 (1.5) 1.0
0.9
1.7–2.0 2.1
2.7
1.7–5.9 2.1
2.5
1.7–5.9 2.2
3.0
1.7–4.8 2.8
2.5
1.7–5.9 2.0
2.8
1.7–4.8 2.4
3.0
1.7–5.9 2.1
2.5
1.7–4.8 2.5
3.0
1.7–4.8 2.0
2.5
1.7–5.9
  0.003 0.505 0.480 0.520 0.565
CCL5/RANTES (0.02) 1.8
1.5
1.1–3.9 3.6
2.3
0.0–76.5 6.3
3.7
0.5–59.4 2.1
2.0
0.0–76.5 8.4
8.5
2.0–59.4 2.9
2.1
0.0–76.5 4.5
5.7
0.0–43.0 3.3
2.1
0.5–76.5 8.9
8.5
0.5–76.5 2.7
2.3
0.0–59.4
  0.091 0.033 0.078 0.355 0.192
CCL3/MIP-1α (4.0) 3.2
3.1
4.1–9.1 4.0
4.9
4.1–15.2 4.5
5.3
4.1–8.0 3.7
4.8
4.1–15.3 3.9
4.2
4.1–8.0 4.1
5.0
4.1–15.3 4.2
4.7
4.1–8.0 4.0
5.2
4.1–15.3 5.0
5.0
4.1–15.3 3.8
4.8
4.1–8.0
  0.812 0.202 0.907 0.931 0.368
CCL4/MIP-1β (3.0) 27.9
24.3
19.0–43.8 34.6
32.3
16.4–190.9 35.5
34.4
16.4–85.0 34.0
30.2
16.9–190.4 33.8
34.4
16.4–85.0 34.8
32.0
16.9–190.4 34.5
32.3
16.4–190.4 35.1
31.8
18.4–85.0 39.7
32.7
16.9–190.4 33.1
30.5
16.4–85.0
  0.350 0.657 0.876 0.821 0.720
CCL2/MCP1 (3.0) 235.9
232.4
140.3–415.5 595.7
417.5
143.4–4230.1 888.6
846.7
214.6–3270.0 447.7
316.9
143.1–4230.1 857.4
846.7
222.7–2536.0 545.6
361.0
143.1–4230.1 767.9
781.0
214.6–3270.0 540.3
356.3
143.1–4230.1 901.0
959.9
143.1–4230.1 519.0
363.9
200.1–3270.0
  0.003 0.033 0.236 0.320 0.157