Figure 1. Initial linkage analysis. A: The family pedigree. Analyzed patients are indicated with asterisks. Full coloration indicates infantile esotropia or Duane retraction syndrome; quarter coloration indicates keratoconus. B: Multipoint linkage analysis (the unaffected parents, all 4 esotropic siblings, and 2 unaffected siblings) revealed maximum logarithm of odds (LOD) scores on chromosomes 3p26.3–26.1 (LOD score 3.18) and 6q24.2–25.1 (LOD score 3.25).