Figure 5. The inhibitory effect of modified RGDRGD-endostatin gene on the area of CNV and the expression VEGF in aqueous humor. A: The inhibitory effect of modified RGDRGD-endostatin gene on the area of CNV. The area of CNV was calculated by the number of newly developed vessels multiplied by the length of the vessels from the limbus, 7 and 14 days after the alkaline burn. B: The concentration of VEGF in aqueous humor (n=10, M±SD). The modified RGDRGD-endostatin gene has a significantly different effect compared with the native gene at 7 and 14 days. Data are expressed as a mean±SD, as well as at other days. ***p<0.001; **p<0.01; *p<0.05, when CNV with treated groups was compared with control group. ^tp<0.05, ^ttp<0.01, when CNV with the combination of RGDRGD-endostatin was compared with CNV treated with native endostatin.