Figure 5. The inhibitory effect of
modified RGDRGD-endostatin gene on the area of CNV and the
expression VEGF in aqueous humor. A: The inhibitory effect of
modified RGDRGD-endostatin gene on the area of CNV. The area of
CNV was calculated by the number of newly developed vessels multiplied
by the length of the vessels from the limbus, 7 and 14 days after the
alkaline burn. B: The concentration of VEGF in aqueous humor
(n=10, M±SD). The modified RGDRGD-endostatin gene has a
significantly different effect compared with the native gene at 7 and
14 days. Data are expressed as a mean±SD, as well as at other days.
***p<0.001; **p<0.01; *p<0.05, when CNV with treated groups
was compared with control group. tp<0.05, ttp<0.01,
CNV with the combination of RGDRGD-endostatin was compared
with CNV treated with native endostatin.