Figure 5. Effects of recombinant AREG and GDF15 proteins on cell proliferation and protein synthesis of SRA01/04 cells. Serum starved SRA01/04 cells were incubated with recombinant AREG, GDF15, or EGF at the indicated concentrations and examined ³H-thymidine (A) or ³H-leucine (B) uptake as described in Methods. Values are expressed as the mean±SD (n=4~5) and presented as % of control (none). Essentially the same results were obtained by three times and representative data are shown. ***p<0.001; **p<0.01; *p<0.05, compared to controls (none).