Figure 5. Transplantation of murine
retinal progenior cells (mRPCs) into Rho−/− mice
combined with chondroitinase ABC or a cocktail. The first row (A-D)
and
the third row (I-L): Transplantation with
chondroitinase ABC. The second row (E-H) and the fourth
row (M-P): Transplantation with a cocktail. The average number
of recoverin-positive (Q) or rhodopsin-positive cells (R)
was counted per microscopic field. The columns are mean values, error
bars are SD *p<0.05 (n=9). The cells (arrow) are recoverin-positive
in the outer nuclear layers and inner nuclear layers (D, H).
The
cells express rhodopsin when they are transplanted with a cocktail (N).
However,
no rhodopsin-positive cells are seen in J. Scale bar:
20 μm (D, H, L); 10 μm (P).
Abbreviations: ganglion cell layer (GCL); inner nuclear layer (INL);
outer nuclear layer (ONL); and subretinal space (SRS).
