Figure 2. Chondroitinase ABC disrupts the chondroitin sulfate proteoglycans (CSPGs) and glial scar barrier in B6 mice. A-D: One week after subretinal transplantation of murine retinal progenior cells (mRPCs). E-H: One week after subretinal transplantation of mRPCs combined with Chondroitinase ABC. I-L: Three weeks after subretinal transplantation of mRPCs. M-P: Three weeks after subretinal transplantation of mRPCs with chondroitinase ABC. Following transplantation of mRPCs and Chondroitinase ABC, the expression of chondroitin (F, N) is much lower than that of B and J. Scale bar: 25 μm (D, H), 20 μm (L, P). Abbreviations: GCL, ganglion cell layer (GCL); inner nuclear layer (INL); outer nuclear layer (ONL); and subretinal space (SRS).