Molecular Vision: Mayinu, Mol Vis 2011; 17:1734-1744. Table 4

Table 4. Haplotype Association analysis between the LOXL1 SNPs and XFS/XFG.

Haplotype			Proportion		χ²	p value	OR (95%CI)
			Case	Control
rs1048661	rs3825942
T	G		0.047	0.181	6.52	0.011	0.22 (0.06–0.77)
G	G		0.922	0.756	7.66	0.006	3.81(1.40–10.34)
G	A		0.031	0.063	0.86	0.353	0.48 (0.10–2.33)
Total					7.90	0.019	NA
rs1048661	rs2165241
T	C		0.031	0.157	6.65	0.010	0.17 (0.04–0.76)
G	T		0.563	0.260	16.89	0.000	3.66 (1.99–6.90)
T	T		0.016	0.024	0.13	0.716	0.66 (0.07–6.44)
G	C		0.391	0.559	4.83	0.028	0.51 (0.27–0.93)
Total					19.21	0.000	NA
rs3825942	rs2165241
G	C		0.406	0.660	11.35	0.001	0.35 (0.19–0.65)
A	T		0.016	0.008	0.25	0.619	2.00(0.12–32.51)
G	T		0.563	0.280	15.00	0.000	3.38 (1.80–6.34)
A	C		0.016	0.055	1.65	0.198	0.27 (0.03–2.26)
Total					16.06	0.001	NA
rs1048661	rs3825942	rs2165241
T	G	C	0.031	0.157	6.65	0.010	0.17 (0.04–0.76)
G	G	C	0.375	0.504	2.85	0.092	0.59 (0.32–1.09)
G	G	T	0.547	0.252	16.25	0.000	3.58 (1.90–6.76)
T	G	T	0.016	0.024	0.13	0.716	0.66 (0.07–6.44)
G	A	C	0.016	0.055	1.65	0.198	0.27 (0.03–2.26)
G	A	T	0.016	0.008	0.25	0.619	2.00(0.12–32.51)
Total					19.93	0.001	NA

The haplotypes G-G for the SNPs rs1048661 and rs3825942, G-T for the SNPs rs1048661 and rs2165241, and G-T for the SNPs rs3825942 and rs2165241 were identified to be significantly associated with XFS/G. The haplotype G-G-T for the three SNPs was identified to be significantly associated with XFS/G. Total indicates omnibus tests, while the others indicate the haplotype-specific tests. The OR values were obtained from comparison of each individual haplotype with all the other haplotypes, i.e., T-G versus G-G + G-A for the SNPs rs1048661 and rs3825942, etc. NA: not available.