Molecular Vision: Mayinu, Mol Vis 2011; 17:1734-1744. Table 3

Table 3. Allele and genotype association analysis for the three SNPs of LOXL1.

SNP	XFS/XFG	Control	χ²	p value	OR (95%CI)
rs1048661
Allele
G	104 (0.81)	176 (0.69)	6.22	0.013	1.92 (1.14–3.22)
T	24 (0.19)	78 (0.31)	6.22	0.013	1.92 (1.14–3.22)
Genotype
GG	42 (0.66)	60 (0.47)	5.78	0.016	2.13 (1.14–3.97)
GT	20 (0.31)	56 (0.44)
TT	2 (0.03)	11 (0.09)	2.06	0.152	0.34 (0.07–1.58)
Total	64	127	6.37	0.041	NA
rs2165241
Allele
T	72 (0.56)	62 (0.24)	37.89	0.000	3.98 (2.54–6.25)
C	56 (0.44)	192 (0.76)	37.89	0.000	3.98 (2.54–6.25)
Genotype
TT	22 (0.34)	10 (0.08)	21.43	0.000	6.13 (2.68–14.01)
CT	28 (0.44)	42 (0.33)
CC	14 (0.22)	75 (0.59)	23.64	0.000	0.19 (0.10–0.39)
Total	64	127	31.79	0.000	NA
rs3825942
Allele
G	122 (0.95)	205 (0.81)	14.73	0.000	4.86 (2.02–11.68)
A	6 (0.05)	49 (0.19)	14.73	0.000	4.86 (2.02–11.68)
Genotype
GG	58 (0.91)	80 (0.63)	16.21	0.000	5.68 (2.28–14.17)
GA	6 (0.09)	45 (0.35)
AA	0 (0.00)	2 (0.02)	1.02	0.313	NA
Total	64	127	16.33	0.000	NA

There were significant differences for the allelic proportion between the patient and control groups for all three SNPs. G allele of rs1048661, G of rs3825942, and T of rs2165241 were risk alleles for the disorder. The genotypes GG for rs1048661, GG for rs3825942, and TT for rs2165241 were risk genotypes for the disease. Total indicates the general test of association in the 2-by-3 table of disease-by-genotype. NA: not available. The asterisks indicates the OR values and p values derived from comparison of the specific genotype with all the others, i.e., GG versus GT+TT at rs1048661, TT versus CT+CT at rs2165241.