Table 3 of Garcia-Ayuso, Mol Vis 2011; 17:1716-1733.

Table 3. Differences between pigmented and albino rats after light-induced retinal degeneration.

Pigmented Albino
1. Pupil dilation
Necessary for phototoxicity. Not necessary, but increases light toxicity at early periods.
2. Light-sensitive “arciform area” in the dorsal retina.
Blood retinal barrier breakdown almost always present in this area. Blood retinal barrier breakdown present in this area only in 41% of the retinas.
Longer duration of HRP leakage (up to one month). Shorter duration of HRP leakage (up to 7 days).
Retinal degeneration in this area much more severe: a very thin retina containing a few cells and the retinal nerve fiber layer remained 1 year ALE. Photoreceptor degeneration starts and is more severe in this area, but only at early periods ALE
3. Diffuse photoreceptor degeneration in areas other than the light sensitive “arciform” area.
Less severe than in albino rats. More severe than in pigmented rats.
4. Axonal compression by retinal vessels.
Two types of axonal compressions: a “localized” in the “arciform area” and a “diffuse” in the rest of the retina. Only is observed the “diffuse” axonal compression
Starts earlier and progresses faster than in albino rats: it is observed 21 days ALE in the light sensitive “arciform” area (causes significant RGC death in the superior retina, see below) and by 4 months ALE has extended throughout the whole retina. This late “diffuse” form of axonal compression is more prevalent in the peripapillary ventral retina. Starts later, at around 3 months and is “diffuse,” although at early times (3–9 months) is more prevalent in the dorsal retina.
5. Retinal Ganglion cell death.
Following the two types of the axonal compressions, there are two types of RGC loss: a “localized” form peripheral to the “arciform area” and a “diffuse” form that sometimes is sectorial (wedge-shaped sectors). RGC death is “diffuse” although at late times ALE it is observed a sectorial (wedge-shaped sectors) loss.
Is more abundant in the superior retina, due to the axonal compressions in the light sensitive “arciform” area. Wedge-shaped sectors lacking RGCs can be seen 9 or more months ALE in the ventral retina. Is diffuse and significant 6 months ALE. Wedge-shaped areas lacking RGCs can be seen at12 months ALE mainly in the ventral retina.
6. Subretinal vascular complexes.
Were seen always in the areas where photoreceptor degeneration was almost complete
Start earlier and are more abundant: could be seen from 7 days ALE in the “arciform area,” from 3 months in the peripapillary and all throughout the ventral retina at 9 months. First seen at around 6 months in the dorsal retina and extended throughout the retina with time ALE.