Molecular Vision: Garcia-Ayuso, Mol Vis 2011; 17:1716-1733. Table 1

Table 1. Temporal course of retinal degeneration after light exposure: effect of eye pigmentation, light source and pupil dilation

Time ALE	Pigmented rats				Albino Sprague-Dawley rats
	(Data from: [6])				3000 lx during 48 h
	3000 l× during 72 h				(n=26)
	Linear Bulbs				Circular Bulbs (n=13)				Linear Bulbs (n=13)
	Dorsal retina		Ventral retina		Dorsal retina		Ventral retina		Dorsal retina		Ventral retina
	Left eye (dilated)	Right eye (undilated)	Left eye (dilated)	Right eye (undilated)	Left eye (dilated)	Right eye (undilated)	Left eye (dilated)	Right eye (undilated)	Left eye (dilated)	Right eye (undilated)	Left eye (dilated)	Right eye (undilated)
0 h	0–1	10–12	2–4	10–12	4–6	5–7	6–8	10–12	5–7	6–8	10–12	10–12
					(n=2)				(n=2)
1 week	0–1	10–12	2–4	10–12	0–1	1–2	2–4	3–5	1–2	1–3	3–5	3–6
					(n=2)				(n=2)
1 month	Reduced OPL. No ONL	10–12	Reduced ONL and OPL	10–12	Reduced OPL. No ONL.		Reduced OPL and ONL (1–3 nuclei).		Reduced OPL and ONL (0–2 nuclei).		Reduced OPL and ONL (1–3 nuclei).
					(n=2)				(n=2)
3 months	No ONL. No OPL. Reduced INL (0–1 nuclei).	10–12	Reduced ONL(0–1 nuclei).	10–12	No ONL. No OPL. Thinner INL (2–3 nuclei). (n=4)
6 months or longer	Very thin retina, no layers. Subretinal vessels. RGC loss.	10–12	Reduced ONL (0–1 nuclei). Thinner INL (1–3 nuclei). Subretinal vessels. RGC loss.	10–12	Very thin INL (1–2 nuclei). Subretinal complexes of vessels. Significant RGC loss. (n=10)

Data from the first column correspond to pigmented Lister-Hooded and pigmented non-dystrophic Royal College of Surgeons rats exposed to 3,000 lx during 72 h from a previous study (Marco-Gomariz et al., 2006, reference [6]). Control animals in this and the previous study and the undilated right eyes of pigmented rats in the previous study showed an outer nuclear layer (ONL) 12 to 14 nuclei thick and an inner nuclear layer (INL) 3 to 4 nuclei thick (not shown). Numbers in 0 h and 1 week rows and in all rows of the right undilated eyes of the pigmented animals refer to the nuclei thickness of the ONL. n=number of animals. ONL: outer nuclear layer, OPL: outer plexiform layer, INL: inner nuclear layer, GCL: ganglion cell layer, NFL: nerve fiber layer. RGC: retinal ganglion cells.