Figure 7. Effect of spiradoline (0.3%, 30 µl) on IOP of conscious Tibetan monkeys. The drug was administered topically at 10 AM (Time 0) onto a randomly assigned eye of each animal, while the contralateral eye received vehicle as control Error bars represent SEM (n=6). Top Panel: IOP values of both groups. *p<0.05, ***p<0.001 between the two treatment groups by two-tailed paired Student's t-test. Bottom panel: % IOP change of the spiradoline group relative to the vehicle control group.