Figure 3. Gel contraction was dose-dependent inhibited by anti-integrin α1β1 and α2β1 antibody. Human fibroblasts were incubated in the absence (mouse anti-human IgG as control) or presence of a combination of anti-human integrin α and anti-human integrin β1 antibodies at final concentrations of 1 µg/ml and 4 µg/ml for 3 days. A: Representative photomicrographs show collagen gel changes. B: Contraction was indicated as percentage of the initial gel surface area.