Table 4 of
Landreville, Mol Vis 2011; 17:1324-1333. Table 4 of
Landreville, Mol Vis 2011; 17:1324-1333.
Table 4. Downregulated genes from the UVM subtracted library.
| Gene | Chromosomal location | GenBank accession# | Biological process | Redundancy | Microarray fold-change UM/UVM* |
|---|---|---|---|---|---|
| Actin gamma 1 (ACTG1) | 17q25.3 | NM_001614 | Motility | 3 | −86.7 |
| A kinase (PRKA) anchor protein 12 (AKAP12) | 6q25 | NM_005100 | G-protein signaling | 1 | −1.91 |
| Alpha-2-macroglobuline (A2M) | 12p13.31 | NM_000014 | Cytokine transport | 3 | −44.4 |
| Cathepsin K (CTSK) | 1q21 | NM_000396 | Proteolysis | 3 | −106.5 |
| Chromosome 1 open reading frame 124 (C1orf124) | 1q42 | NM_032018 | DNA repair | 2 | −0.62 |
| Chromosome 18 open reading frame 32 (C18orf32) | 18q21.1 | NM_001035005 | NF-kappaB cascade regulation | 1 | −2.69 |
| Dynein cytoplasmic 1 light intermediate chain 2 (DYNC1LI2) | 16q22.1 | NM_006141 | Endosome transport | 1 | −2.61 |
| E74-like factor 1 (ets domain transcription factor) (ELF1) | 13q13 | NM_172373 | Transcription | 1 | −1.83 |
| Endothelin receptor type B (EDNRB) | 13q22 | NM_000115 | Melanocyte differentiation | 1 | −38.9 |
| Epithelial membrane protein 1 (EMP1) | 12p12.3 | NM_001423 | Epithelial cell differentiation | 1 | −148.8 |
| Formin binding protein 4 (FNBP4) | 11p11.2 | NM_015308 | Unknown | 1 | −7.82 |
| Glycoprotein (transmembrane) nmb (GPNMB) | 7p15 | NM_002510 | Melanocyte differentiation | 1 | −84.5 |
| Guanine nucleotide binding protein alpha inhibiting polypeptide 3 (GNAI3) | 1p13 | NM_006496 | G-protein signaling | 2 | −0.82 |
| Guanine nucleotide binding protein (G protein) gamma 11 (GNG11) | 7q21 | NM_004126 | G-protein signaling | 1 | −6.56 |
| Heterochromatin protein 1 binding protein 3 (HP1BP3) | 1p36.12 | NM_016287 | Nucleosome assembly | 1 | −2.37 |
| Importin 7 (IPO7) | 11p15.4 | NM_006391 | Protein transport | 2 | −0.64 |
| Junction mediating and regulatory protein p53 cofactor (JMY) | 5q14.1 | NM_152405 | Apoptosis | 1 | −1.68 |
| Leucine rich repeat containing 39 (LRRC39) | 1p21.2 | NM_144620 | Unknown | 1 | −3.90 |
| Lysophosphatidic acid receptor 6 (LPAR6) | 13q14 | NM_005767 | G-protein signaling | 2 | −20.7 |
| Methylthioadenosine phosphorylase (MTAP) | 9p21 | NM_002451 | Polyamine metabolism | 1 | −2.55 |
| Nerve growth factor receptor associated protein 1 (NGFRAP1) | Xq22.2 | NM_206915 | Apoptosis | 1 | −2.45 |
| Potassium channel tetramerisation domain containing 18 (KCTD18) | 2q33.1 | NM_152387 | Potassium ion transport | 1 | −1.33 |
| Potassium inwardly-rectifying channel subfamily J member 13 (KCNJ13) | 2q37 | NM_002242 | Potassium ion transport | 2 | −21.9 |
| Proteolipid protein 1 (PLP1) | Xq22 | NM_000533 | Glial cell differentiation | 4 | −5.78 |
| Rho-related BTB domain-containing protein 3 (RHOBTB3) | 5q15 | NM_014899 | Retrograde transport | 1 | −2.69 |
| Ribosomal protein S6 kinase polypeptide 1 (RPS6KC1) | 1q41 | NM_012424 | Protein phosphorylation | 1 | −1.64 |
| SLIT and NTRK-like family member 2 (SLITRK2) | Xq27.3 | NM_032539 | Axonogenesis | 2 | −2.51 |
| SRY (sex determining region Y)-box 4 (SOX4) | 6p22.3 | NM_003107 | Transcription | 1 | −1.26 |
| Subunit of the oligosaccharyltransferase complex homolog B (STT3B) | 3p23 | NM_178862 | Protein glycosylation | 2 | −1.50 |
| Transcription elongation factor A (SII)-like 7 (TCEAL7) | Xq22.1 | NM_152278 | Transcription | 1 | −2.82 |
| Transmembrane emp24 protein transport domain containing 7 (TMED7) | 5q22.3 | NM_181836 | ER transport | 2 | −1.15 |
| Testis-specific protein-like 1, y-encoded (TSPYL5) | 8q22.1 | NM_033512 | Nucleosome assembly | 1 | −4.02 |
| Tyrosinase-related protein 1 (TYRP1) | 9p23 | NM_000550 | Melanocyte differentiation | 1 | −397 |
| Ubiquitin-conjugating enzyme E2H (UBE2H) | 7q32 | NM_003344 | Protein ubiquitination | 1 | −2.32 |
| WW domain binding protein 5 (WBP5) | Xq22.2 | NM_016303 | Unknown | 1 | −2.54 |
| Zinc finger AN1-type domain 5 (ZFAND5) | 9q21 | NM_006007 | Development | 2 | 0.61 |