Figure 2. Protein alignment of 12 (TSPAN12) orthologs demonstrates conservation in the regions with mutations. The 12 orthologs are from the following 12 species: Homo sapiens (NP_036470), Pan troglodytes (XP_001142304), Mus musculus (NP_766595), Rattus norvegicus (Q569A2), Bos taurus (NP_001039977), Equus caballus (XP_001502093), Canis familiaris (XP_855095), Monodelphis domestica (XP_001364876), Gallus gallus (NP_001007850), Taeniopygia guttata (XP_002192381), Ornithorhynchus anatinus (XP_001516347), and Danio rerio (NP_957446). The regions with the two missense mutations are highly conserved. T49M stands for p.Thr49Met and C105R stands for p.Cys105Arg.