Logistic regression model was used to calculate odds ratio (OR) and 95% confidence interval (CI) for early or late AMD, comparing ε2 or ε4 allele carriers vs ε3ε3 genotype as reference. The ε2 carrier includes genotypes of ε2ε2 and ε2ε3, whereas the ε4 carrier includes genotypes of ε3ε4 and ε4ε4. Subjects with ε2ε4 genotype (3 in controls, 4 in early AMD, 4 in exudative AMD) are excluded from either ε2 or ε4 carrier. APOE risk scores were evaluated by respectively assigning +1, 0, or −1 per ε2, ε3, or ε4 allele. As a result, genotypes of ε2ε2, ε2ε3, ε2ε4, ε3ε3, ε3ε4, and ε4ε4 would have scores of +2, +1, 0, 0, −1, and −2, respectively. Data are expressed as OR (95%CI). Adjusted OR represents data after adjustment for age, gender and cigarette smoking.