Table 5 of Hughes, Mol Vis 2011; 17:983-988.

Table 5. Review and meta-analysis of all identified previous reports of rs12614 (R32W) polymorphism in AMD

Study Case phenol
type Population Study size Cases Controls 32W 32Q
32W 32Q 32R 32W 32Q 32R OR 95%CI P OR 95%CI P
Current study NV European 618 52 39 643 49 58 395 0.65 0.42–1.00 0.04 0.41 0.26–0.64 2.9x10−05
[10] NV European-American 548 52 21 473 55 61 434 0.87 0.57–1.32 0.49 0.32 0.18–0.54 4.2 x10−06
[18] NV Caucasian 629 70 37 731 41 48 330 0.77 0.50–1.18 0.21 0.35 0.22–0.56 1.7 x10−06
[10] GA European-American 366 20 4 158 55 61 434 1.00 0.56–1.77 1.00 0.18 0.05–0.53 2.7 x10−04
[10] Early European-American 459 37 19 312 55 61 434 0.94 0.59–1.49 0.77 0.43 0.24–0.76 1.7 x10−03
[10] NV, GA, Early European-American 823 109 44 943 55 61 434 0.91 0.64–1.31 0.60 0.33 0.22–0.51 2.6 x10−08
[19] NV, GA Indian 351 52 27 274 55 90 204 0.70 0.45–1.09 0.10 0.22 0.14–0.36 3.1 x10−11
[5] NV, GA, Drusen Caucasian 179 25 6 193 7 10 117 2.17 0.86–5.69 0.08 0.36 0.11–1.12 0.05
Meta-analysis NV   1795 174 97 1847 145 167 1159 0.75 0.59–0.96 0.02 0.36 0.28–0.47 4.6 x10−15
Meta-analysis All   2600 308 153 2784 207 267 1480 0.79 0.65–0.96 0.01 0.30 0.25–0.38 1.8 x10−31

p values calculated using Pearson’s χ2 test and allelic model. The odds ratios and p values for 32W and 32Q are calculated with reference to 32R. Phenotype and population descriptions are as reported in the original papers. NV=Neovascular AMD; GA=Geographic Atrophy; OR=Odds Ratio; CI=Confidence Interval; p=p value. The numbers from the Spencer et al. [18] and Kaur et al. [19] papers are derived from reported percentages and frequencies, therefore may be slightly inaccurate.

Hughes, Mol Vis 2011; 17:983-988. http://www.molvis.org/molvis/v17/a109

©2011 Molecular Vision http://www.molvis.org/molvis/

ISSN 1090-0535