Table 4 of Hughes, Mol Vis 2011; 17:983-988.

Table 4. Logistic regression of complement factor B (CFB) codon 32 type, complement factor H (CFH) haplotypes, HTRA1rs10490924 genotype and smoking status.

Covariates Odds ratio 95% Confidence interval P value
    Lower Upper  
CFH haplotype 1 1.91 1.20 3.04 6.7×10−3
CFH haplotype 2 2.41 1.64 3.52 6.5×10−6
CFH haplotype 4 1.12 0.71 1.75 0.63
CFH haplotype 5 0.47 0.28 0.78 4.0×10−3
CFB 32W 0.53 0.31 0.91 0.02
CFB 32Q 0.33 0.19 0.56 5.1×10−5
HTRA1 risk heterozygote (AT) 3.40 2.20 5.26 3.9×10−8
HTRA1 risk homozygote (TT) 25.04 11.24 55.78 3.3×10−15
Ex-smoker 1.73 1.10 2.71 0.02
Current smoker 3.61 2.00 6.49 1.9×10−5
Regression constant 0.29     5.9×10−5

A logistic regression of genetic variants and smoking status. CFB and CFH data were coded as 0, 1 or 2 copies of each allele. Complete data were available for 351 cases and 222 controls to allow inclusion in the logistic regression model. CFH haplotypes are defined in Methods.

Hughes, Mol Vis 2011; 17:983-988. http://www.molvis.org/molvis/v17/a109

©2011 Molecular Vision http://www.molvis.org/molvis/

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