Figure 5. Correlation of OD and OS tear cytokine/chemokine levels with corresponding OD and OS clinical measurements of tear production and ocular surface integrity in DED patients. IL-1Ra, IL-8/CXCL8, and Fractalkine/CX3CL1 levels correlated negatively with tear production tests, and IL-6 levels correlated positively with rose Bengal staining test (measuring ocular surface integrity). A: Schirmer test, B: lysozyme levels, C: BUT, and D: Rose Bengal staining. Cytokine/chemokine values are expressed in pg/ml in a 100× (IL-1Ra, IL-8 and fractalkine) or 10× (IL-6) scale. Spearman's rho correlation coefficient was determined. Dotted lines indicate the 95% confidence bands. IL, interleukin; IL-1Ra, interleukin 1 receptor antagonist; OD, right eye; OS, left eye.