Table 2 of
Mitra, Mol Vis 2010; 16:828-842. Table 2 of
Mitra, Mol Vis 2010; 16:828-842.
Table 2. Down-regulated genes identified by microarray post EpCAM Knock-down in Y79
| Gene classification/description | Gene symbol | Fold change | GenBank accession | Chromosome location |
|---|---|---|---|---|
| Proliferation | ||||
| Homo sapiens fibroblast growth factor 9 (glia-activating factor) | FGF9 | −1.09836 | [NM_002010] | 13q12.11 |
| Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) | FOS | −2.42289 | [NM_005252] | 14q24.3 |
| Homo sapiens jun oncogene (JUN) | JUN | −1.65468 | [NM_002228] | 1p32.1 |
| Homo sapiens E2F transcription factor 3 (E2F3), mRNA | E2F3 | −0.57954 | [NM_001949] | 6p22.3 |
| Homo sapiens proliferating cell nuclear antigen (PCNA), transcript variant 1, mRNA | PCNA | −1.53558 | [NM_002592] | 20p12.3 |
| Homo sapiens high mobility group AT-hook 2 (HMGA2), transcript variant 1, mRNA | HMGA2 | −1.70144 | [NM_003483] | 12q14.3 |
| Homo sapiens hairy and enhancer of split 1, (Drosophila) (HES1), mRNA | HES1 | −2.41369 | [NM_005524] | 3q29 |
| Homo sapiens cyclin D3 (CCND3), mRNA | CCND3 | −2.27265 | [NM_001760] | 6p21.1 |
| Homo sapiens growth arrest and DNA-damage-inducible, alpha (GADD45A), mRNA | GADD45A | −1.0626 | [NM_001924] | 1p31.3 |
| Homo sapiens ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (ELAVL1), mRNA | ELAVL1 | −1.04274 | [NM_001419] | 19p13.2 |
| Homo sapiens nuclear receptor coactivator 1 (NCOA1), transcript variant 3, mRNA | NCOA1 | −1.24715 | [NM_147233] | 2p23.3 |
| Homo sapiens electron-transferring-flavoprotein dehydrogenase (ETFDH), nuclear gene encoding mitochondrial protein, mRNA | ETFDH | −1.69508 | [NM_004453] | 4q32.1 |
| Homo sapiens myotubularin related protein 9 (MTMR9), mRNA | MTMR9 | −1.26689 | [NM_015458] | 8p23.1 |
| Homo sapiens protein tyrosine phosphatase type IVA, member 1 (PTP4A1), mRNA | PTP4A1 | −1.18325 | [NM_003463] | 6q12 |
| Homo sapiens CCHC-type zinc finger, nucleic acid binding protein (CNBP), mRNA | CNBP | −1.07756 | [NM_003418] | 3q21.3 |
| Homo sapiens enolase 1, (alpha) (ENO1), mRNA | ENO1 | 1.24292 | [NM_001428] | 1p36.23 |
| Homo sapiens insulin-like growth factor 1 (somatomedin C) (IGF1), mRNA | IGF1 | −1.41077 | [NM_000618] | 12q23.2 |
| Homo sapiens Ewing sarcoma breakpoint region 1, mRNA (cDNA clone MGC:8607 IMAGE:2961279) | EWSR1 | −1.10194 | [BC000527] | 22q12.2 |
| Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), mRNA | SPRED1 | −1.28822 | [NM_152594] | 15q14 |
| Cell invasion | ||||
| Homo sapiens cell division cycle 42 (GTP binding protein, 25 kDa) (CDC42), transcript variant 2, mRNA | CDC42 | −0.79444 | [NM_044472] | 1p36.12 |
| Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase) (MMP2), mRNA | MMP2 | −0.67629 | [NM_004530] | 16q12.2 |
| Homo sapiens plexin A1 (PLXNA1), mRNA | PLXNA1 | −1.07618 | [NM_032242] | 3q21.3 |
| Homo sapiens protein tyrosine phosphatase type IVA, member 1 (PTP4A1), mRNA | PTP4A1 | −1.18325 | [NM_003463] | 6q12 |
| Homo sapiens MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) (MEF2A), mRNA | MEF2A | −1.17285 | [NM_005587] | 15q26.3 |
| Homo sapiens methylthioadenosine phosphorylase (MTAP), mRNA | MTAP | −1.75238 | [NM_002451] | 9p21.3 |
| Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (YWHAZ), transcript variant 2, mRNA | YWHAZ | −1.02872 | [NM_145690] | 8q22.3 |
| Angiogenesis | ||||
| Homo sapiens dual specificity phosphatase 1 (DUSP1), mRNA | DUSP1 | −2.09785 | [NM_004417] | 5q35.1 |
| Homo sapiens malignant T cell amplified sequence 1 (MCTS1), mRNA | MCTS1 | −1.16085 | [NM_014060] | Xq24 |
| Oncogene | ||||
| Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), mRNA | RAP2C | −1.29212 | [NM_021183] | Xq26.2 |
| Homo sapiens RAB8A, member RAS oncogene family (RAB8A), mRNA | RAB8A | −1.02394 | [NM_005370] | 19p13.12 |
| Homo sapiens sarcospan (Kras oncogene-associated gene) (SSPN), mRNA | SSPN | −1.31047 | [NM_005086] | 12p12.1 |
| Homo sapiens RAB1B, member RAS oncogene family (RAB1B), mRNA | RAB1B | −1.29331 | [NM_030981] | 11q13.1 |
| Homo sapiens RAB15, member RAS onocogene family (RAB15), mRNA | RAB15 | −1.64564 | [NM_198686] | 14q23.3 |
| Homo sapiens v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN), mRNA | MYCN | −0.50087 | [NM_005378] | 2p24.3 |
| Antiapoptotic | ||||
| Homo sapiens DnaJ (Hsp40) homolog, subfamily A, member 3 (DNAJA3), mRNA | DNAJA3) | −1.11925 | [NM_005147] | 16p13.3 |
| Homo sapiens ornithine decarboxylase 1 (ODC1), mRNA | ODC1 | −1.56073 | [NM_002539] | 2p25.1 |
| Homo sapiens gelsolin (amyloidosis, Finnish type) (GSN), transcript variant 2, mRNA | GSN | −1.1058 | [NM_198252] | 9q33.2 |
| Homo sapiens BCL2-like 1 (BCL2L1), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA | BCL2L1 | −1.06389 | [NM_001191] | 20q11.21 |
| Homo sapiens high-mobility groupbox 1 (HMGB1), mRNA | HMGB1 | −1.00917 | [NM_002128] | 13q12.3 |
| Cell cycle and differentiation | ||||
| Homo sapiens bol, boule-like (Drosophila) (BOLL), transcript variant 2, mRNA | BOLL | −1.03287 | [NM_033030] | 2q33.1 |
| Homo sapiens tubulin, epsilon 1 (TUBE1), mRNA | TUBE1 | −1.10675 | [NM_016262] | 6q21 |
| Homo sapiens eukaryotic translation elongation factor 1 epsilon 1 (EEF1E1), mRNA [NM_004280] | EEF1E1 | −1.04824 | [NM_004280] | 6p24.3 |
| Homo sapiens MAD1 mitotic arrest deficient-like 1 (yeast) (MAD1L1), transcript variant 1, mRNA | MAD1L1 | −1.48937 | [NM_003550] | 7p22.3 |
| Homo sapiens MYC-associated zinc finger protein (purine-binding transcription factor) (MAZ), transcript variant 1, mRNA | MAZ | −1.00923 | [NM_002383] | 16p11.2 |
| Homo sapiens O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) (OGT), transcript variant 1, mRNA | OGT | −1.2658 | [NM_181672] | Xq13.1 |
| Homo sapiens U2 small nuclear RNA auxiliary factor 1 (U2AF1), transcript variant a, mRNA | U2AF1 | −1.02281 | [NM_006758] | 21q22.3 |
| Homo sapiens tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase (TRMU), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA | TRMU | −1.24944 | [NM_018006] | 22q13.31 |
| Homo sapiens CNDP dipeptidase 2 (metallopeptidase M20 family) (CNDP2), mRNA | CNDP2 | −1.29951 | [NM_018235] | 18q22.3 |
| Homo sapiens pinin, desmosome associated protein (PNN), mRNA | PNN | −1.02816 | [NM_002687] | 14q21.1 |
| Homo sapiens pericentriolar material 1 (PCM1), mRNA | PCM1 | −1.05392 | [NM_006197] | 8p22 |
| Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL). | PBX1 | −1.42582 | [NM_002585] | 1q23.3 |
| Homo sapiens oxidative stress induced growth inhibitor family member 2 (OSGIN2), mRNA | OSGIN2 | −1.15358 | [NM_004337] | 8q21.3 |
| Homo sapiens zinc finger RNA binding protein (ZFR), mRNA | ZFR | −1.10655 | [NM_016107] | 5p13.3 |
| Homo sapiens PRP4 pre-mRNA processing factor 4 homolog B (yeast) (PRPF4B), mRNA | PRPF4B | −1.10445 | [NM_003913] | 6p25.2 |
| Homo sapiens FUS interacting protein (serine/arginine-rich) 1 (FUSIP1), transcript variant 2, mRNA | FUSIP1 | −1.45444 | [NM_054016] | 1p36.11 |
| Homo sapiens basic leucine zipper and W2 domains 1 (BZW1), mRNA | BZW1 | −1.07595 | [NM_014670] | 2q33.1 |
| Homo sapiens cyclin-dependent kinase 6 (CDK6), mRNA | CDK6 | −0.5 | [NM_001259] | 7q21.2 |
| Homo sapiens cyclin-dependent kinase 4 (CDK4), mRNA | CDK4 | −0.513 | [NM_000075] | 12q14.1 |