Figure 9. Lysosomal acidity is decreased after siramesine treatment. As shown by the marked decrease of red staining indicating the alkalinization of the lysosomal pH. The sample was excited with the UV–laser. Human lens epithelial cells (HLEC) were stained with acridine orange (red) and Hoechst (blue) after incubation with 10 µM siramesine (B) and solvent, 1% DMSO (A). One of two experiments is shown.