Figure 6. Electroretinogram analysis of the choroidal neovascularization-induced alterations in retina function after topical thioredoxin-vasostatin 48 application. The function of retina cells in choroidal neovascularization (CNV) rats was evaluated by electroretinogram (ERG) on day 35 after topical thioredoxin (TRX) and TRX-fused vasostatin 48 (TRX-VS48) treatment (n=24). A: The representative electroretinogram tracings of TRX-treated (left panel) and TRX-VS48-treated (right panel) eyes. B: Effect of TRX-VS48 on a-wave amplitude. The a-wave amplitude significantly increased in the TRX-VS48 eyes *(p<0.05). C: Effect of TRX-VS48 on b-wave amplitude. The b-wave amplitude significantly increased in the TRX-VS48 eyes; *(p<0.05). D: Effect of TRX-VS48 on a-wave latency. The a-wave latency was significantly decreased in the TRX-VS48 eyes *(p<0.05). E: Effect of TRX-VS48 on b-wave latency. No significant difference in the b-wave latency was found between TRX and TRX-VS48 groups.