Figure 3. Genotype analysis of the FOXE3 mutation. A: DNA sequencing chromatograms showing homozygote mutant and carrier status for two individuals. B: Microsatellite analysis for one affected form of the Pakistani and Madagascan families demonstrate segregation of different haplotypes in the two families which exclude an ancestral origin for the mutation p.Cys240X. C: Schematic presentation of the FOXE3 protein. Recessive inherited mutations (R) and dominant mutations (D) are clearly denoted [3-6].