Figure 1. Pedigree structure of the family
with USH2/RP. Affected males and females are shown with filled squares
and circles, respectively. Normal individuals are shown with empty
symbols. The deceased individual is shown with slash. The proband
(III:5) is indicated by an arrow. Results from genotyping and haplotype
analysis of two markers on chromosome 1 are displayed below each
symbol. The disease haplotype is shown with a black or a gray box and
the normal haplotypes are shown with open boxes. The USH2A gene
is located between D1S213 and D1S425. The homozygous individual (IV:1),
whose haplotype is different from other patients, is indicated by an
asterisk. Four patients (III:1, III:3, III:5) are affected with USH2,
and patient (IV:1) displays nonsyndromic RP symptom.