Figure 10. Immunohistochemical localization of retinal outer segment membrane protein 1 (Rom1) and peripherin/rds (Prph2) in the retinas of 3-week-old Rom1^+/+, Rom1^Rgsc1156/+, and Rom1^{Rgsc1156/Rgsc1156} mice. Rom1 immunoreactivity was decreased in the outer segments of the heterozygotes (B) in comparison with wild-type mice (A), and Rom1 immunoreactivity was markedly reduced in the homozygotes (C). Prph2 immunoreactivity in the outer segment was also decreased (E, F, G). No signals were detected in the retinas of wild-type mice when peptide absorption tests were performed (D, H). The bar represents 50 µm. GCL, IPL, INL, OPL, ONL, IS, OS, and RPE refer to ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer, outer nuclear layer, inner segment, outer segment, and retinal pigment epithelium.