Figure 3. Angiographic analysis of choroidal neovascularization (CNV)-associated leakage clouds. A: The graph represents the frequency of occurrence of clinically relevant lesions. The percent occurrence of only lesions considered clinically analogous to human lesions are shown. This comparison of lesions from control and neuroprotecin D1 (NPD1)-treated animals at 7 and 14 days post-laser treatment (from Figure 2) shows an approximate reduction in occurrence of >40% when NPD1 retinas are compared to controls. B: The graph represents the leakage cloud areas from all laser lesions. Following administration of fluorescein (intraperitoneal), the resulting cloud formed at each lesion site was imaged at 1 and 5 min. Early and late images of each lesion were presented serially in a randomized and blind fashion to an observer who manually outlined the leakage area. The graph represents adjusted means produced using a general linear model. Leakage growth was significantly lower in NPD1-treated animals than in controls at both 7 and 14 days. Asterisks denote level of statistical significance as compared to vehicle (*p<0.05; **p<0.01; *** p<0.001).