Figure 1. Color fundus photographs showing fundus autofluorescence (AF) imaging and horizontal spectral domain optical coherence tomography (OCT) scans of affected individuals. A–C: patient 1 at 44 years of age; D–F: patient 2 at 45 years of age. Fundus pictures show widespread retinal pigment epithelium (RPE) alterations and yellowish subretinal deposits along the vascular arcades as well as yellow-white material in the maculae (A, D). Changes are more visible on AF imaging as diffuse, discrete areas of hyper and hypoautofluorescence (B, E). On OCT, intraretinal or subretinal fluids as well as atrophy are shown (C, F).