Figure 2. Retinal ganglion cell viability of eight experiments under (A) glutamate-induced neurotoxicity, (B) oxidative stress, and (C) hypoxic stress. The neuroprotective effect of 1 μM brimonidine was reproduced in all three stresses. The effect of brimonidine on the increase in retinal ganglion cell (RGC) viability was blocked by the α2-adrenergic antagonist yohimbine in all three stresses. Abbreviations: (+) represents control RGC cultures with glutamate; AO(+) represents medium with anti-oxidant; AO(-) represents medium without anti-oxidant; B represents RGC cultures with brimonidine added; B+Y represents RGC cultures with brimonidine and yohimbine added; Y represents RGC cultures with yohimbine added; *, p<0.001; n=7. Error bar indicates SD.