New sequence alterations were identified in cBEST1 exon 10 in Bernese mountain dog, Jämthund, Lapponian herder, and Norfolk terrier breeds. Three dog breeds from Italian kennels (Dogue de Bordeaux, English mastiff, Italian cane corso) were found to carry the cmr1 allele [24] in concordance with their mastiff-related background, while the two mutations in the Lapponian herder segregate with an independent disease form, termed cmr3. Significance of probability for missense mutations to alter protein function was calculated using SIFT (column six; Significance [p]). *Changes were observed in heterozygote state only.