Figure 2. Representative Lapponian herder pedigree analyzed for canine multifocal retinopathy 3 (cmr3) mutations. All animals clinically affected with cmr3 (red) are homozygous for the identified cmr3 haplotype (AA), as is one individual presenting multifocal retinal dysplasia (MRD; gray, arrow). Additionally, one dog diagnosed
with progressive retinal atrophy (PRA) at 8 years of age (black, arrow) shares the disease haplotype; at the same time this
animal is related to non-progressive rod-cone degeneration (prcd) PRA-affected dogs through one of its ancestors (*; extended pedigree not shown). Abbreviations: AB represents the heterozygote
haplotype; BB represents the wild-type haplotype, N/A is not available.