Figure 4. Domain architecture and amino acid sequence comparison of eyes shut homolog (EYS), orthologs and human laminin α1 (LAMA1) laminin G domains. A: Domain architecture of human EYS is shown, indicating the position of mutations in the functional domains. Variants p.D2767Y and p.D3028Y are located in the fourth and fifth laminin A G-like domains, respectively. B: Sequence comparison of laminin A G-like domains of human EYS with its orthologs and human LAMA1. The arrow indicates the position of the mutated aspartic acid residue in the alignment.